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Possibly, this therapy might equally include the myocardial infarction (for review, see, i.e., [19,24,27,29,31,37,38,39,40]), arrhythmias (for review, see, i.e., [19,22,23,24,27,28,29,31,37,38,39,40,41]), acute and chronic heart failure [19,24,27,29,31,37,38,39,40,41] and pulmonary hypertension [41] and thrombosis [18,19,23,24,27,28,29,31,37,38,39,40], prevention and reversal, all as interrelated and closely connected effects

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For an oral peptide, several barriers matter: the compound must remain sufficiently stable during administration, it must pass through the gastrointestinal environment, enough of the relevant chemical species must cross the intestinal barrier, it must survive metabolism, and it must reach the relevant tissue in a biologically meaningful form