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Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is significantly decreased in NASH, and palmitic acid (PA) binds to PRDX1 and inhibits its peroxidase activity
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Regarding the molecular mechanism of NRF2 activation, we identified Cys 226 and Cys 613 as KEAP1 residues that sense NACET treatment through their conjugation with intracellular free Cys, whose concentration is rapidly pushed up by NACET decay
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