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Full article: LC-MS/MS based detection and characterization of covalent glutathione modifications formed by reactive drug of abuse metabolites
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For instance, N -acetyl- p -benzoquinone imine (NAPQI) protein adducts trigger mitochondrial oxidative/nitrosative stress during hepatocyte necrosis, danger-associated molecular patterns (DAMPs) are released to elicit sterile inflammation, and certain growth factors contribute to liver regeneration
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