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Glutamate–cysteine ligase catalytic subunit (GCLC) initiates glutathione synthesis by linking cysteine and glutamate (64).Mitochondrial metabolism is the primary source of cellular reactive oxygen species (ROS), and the breakdown of glutamine is thought to influence ferroptosis by providing α-ketoglutarate (α-KG) in the mitochondrial TCA cycle (65)
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doi: 10.1038/S41591-021-01296-8 44 HuangX.YangX.NiJ.XieB.LiuY.XuanD.et al
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