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FIGURE 4 The expression of both HGF and MET receptor mRNA is strongly increased in response to cerebral ischemic injury (Honda et al., 1995)

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4.3 Creating potassium/calcium channels by ORF3a One of the important capabilities of the viral ORF3a protein is the ability to create ion channels that decrease the concentration of K i + and increase Ca i 2+ in the cell ( i + concentration leads to decreased membrane potential, which can activate voltage-dependent calcium channels (VDCCc) (283, 284), which further increases Ca i 2+ , and one of the possible effects is the activation of calcium-activated potassium channels (KCa), which further decreases K i + concentration (285)