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3 Antitumor mechanisms of methionine restriction 3.1 Methionine restriction exerts antitumor effects by influencing epigenetic regulation In the field of cancer epigenetics, DNA methylation exhibits dual dysregulation characterized by genome-wide hypomethylation and specific hypermethylation of approximately 60–70% of gene promoters containing Cytosine-phosphate-Guanine (CpG) islands, particularly those related to tumor suppressor genes, leading to their transcriptional silencing (32–34)
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