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doi: 10.1046/j.1523-1755.1999.00300.x [DOI] [PubMed] [Google Scholar] 177

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they decrease the amount of time it takes to get to meaningful data, making the study less expensive to perform and less onerous on participants.3 Large loading phase doses have also been shown to be safe in all of these studies, with potential GI effects among the only downsides.9 That means, if you can stomach it, a loading phase can jump-start creatine’s ability to help you build more muscle