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Hepatic Microsomal Ethanol-Oxidizing System (MEOS): CYP2E1 🧬 Chronic alcohol consumption doesn't just increase tolerance—it rewires liver metabolism. The CYP2E1 enzyme, part of the MEOS pathway, becomes upregulated and plays a key role

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The most dangerous window is the first 48 hours to two weeks of correcting severe deficiency, when restarted red cell production can cause hypokalemia (with reported fatal arrhythmias), rebound thrombocytosis, gout flares, and pulmonary edema in fragile patients—so potassium should be checked at baseline and around day 3–7 in severely anemic patients (hemoglobin 6–8), those on diuretics, or those with kidney disease.