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For instance, the researchers portrayed the changes occurring in the development of hCS as a result from the heterozygous PSEN1 L435F mutation that leads to a reduction in mature neurons within the post-mitotic phase, an increase of cell sizes and progenitors, changes to the expression of amyloid beta and alterations in neuronal function

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Size:12lb

NRF2 is a master regulator of antioxidant response as a transcription factor regulating expression of several enzymes responsible for glutathione synthesis, including glutamate-cysteine ligase modifier subunit (GCLM) and the glutamate-cysteine catalytic subunit (GCLC), as well as enzymes related to GSH utilization, such as glutathione reductase, glutathione peroxidase and glutathione S transferase (GST) [45,46]

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