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Due to its complex structure and dual cofactor forms, vitamin B 12 undergoes an elaborate series of absorptive and processing steps before serving as cofactor for the enzymes methylmalonyl-CoA mutase and methionine synthase

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The differential is not marginal — it is the difference between a compound that ran a full clinical program and failed to prove efficacy, and one that has demonstrated both efficacy and cardiovascular benefit in some of the largest obesity trials ever conducted