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Hypertrophic astrocytes maintain the integrity of neuronal tissue and form a barrier that isolates healthy neurons and protects them from neuroinflammatory signals, although at the same time they activate a survival mechanism that may limit the neurotrophic, bioenergetic and antioxidant supply to RGCs

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Antioxidants can inhibit lipid peroxidation by removing molecular oxygen or by decreasing the local concentration of molecular oxygen, removing pro-oxidative metal ions, trapping aggressive ROS, scavenging chain initiating radicals, breaking the chain of free radical reactions, and quenching singlet oxygen [7,41]

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