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All-grade AEs were substantially lower in the group of patients treated with pembrolizumab monotherapy (26%) than in the groups of patients who received chemotherapy in combination with pembrolizumab (75%) or cetuximab (66%).15 The rate of grade 3 or higher AEs was highest in the group given pembrolizumab plus chemotherapy (47%), followed by 39% in the group given cetuximab plus chemotherapy and 7% for patients given pembrolizumab monotherapy
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