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Some metabolites of morphine with electrophilic centers are powerful Michael acceptors of GSH (Correia et al., 1984)
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204 Similarly, administration of the PRMT5 inhibitor PJ-68 in a CML mouse model with high expression of PRMT5 LSCs could deplete DVL3, thereby inhibiting Wnt/β-catenin signaling and significantly prolonging the survival time of a retroviral BCR-ABL-driven CML mouse model
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