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Limitations of MSC treatment in MS are the inconstant access of MSC to the multifocal MS lesions and difficulties in monitoring the fate of MSC once they are administered, the adverse effects of CNS inflammatory environment in MS, the lack of standardized methodological approaches and the heterogeneity of MSCs culture, reagents and techniques which raise the need of standard protocols for laboratory management of MSCs to mitigate inconsistency [71]
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The Long COVID-19 Wearable Device Study (NCT05741112) employs continuous monitoring of sleep, activity, heart rate, and HRV in order to objectively quantify symptoms including PEM and fatigue severity
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