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GHK-Cu exists as a 1:1 copper(II):peptide complex in which the Cu(II) ion is coordinated by the glycine terminal amino group, the amide nitrogen between glycine and histidine, the histidine imidazole nitrogen, and the lysine side chain amino group in a square planar arrangement

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The non-toxicity of Vitamin B12 is confirmed by the US National Institute of Health Office of Dietary Supplements which states that the US Institute of Medicine has not established any upper limit for B12 ‘because of its low toxicity’