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8-hydroxyguanine (8-OHG) activates the cGAS-STING-IRF3 axis, which significantly increases IFN-β secretion and promotes M1 polarization

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Take IBD as an example, by using 16S rRNA gene sequencing to detect and compare the intestinal microbial composition of 26 Crohn’s disease (CD) patients and 14 non-IBD controls, Nishino et al showed an evident decline in the abundance of the phyla Firmicutes and Bacteroidetes, along with an obvious elevation in the abundance of the phylum Proteobacteria in CD patients