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Soya beans are also able to mitigate obesity-induced metabolic disorders [350] as they lower triglyceride levels and have fatty acid synthase inhibitory activity, which contribute to ameliorating diabetes-related complications [351]
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Moreover, longer target engagement compared to IN-8a (noncovalent, N-acetylated IN-8 core) or even to CA-IN-8 (the reversible, cyanoacrylamide containing benchmark compound) was confirmed by similar wash-out experiments in HEK293T cells using the NanoBRET target engagement assay (Fig
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