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Nevertheless, SNACET can be quantitatively analyzed by GC–MS using singly or doubly stable-isotope labeled internal standards such as S 15 NACET, [ acetylo - 2 H 3 ]-SNACET or [ acetylo - 2 H 3 ]-S 15 NACET after their extraction from aqueous buffered solutions and biological samples with ethyl acetate [30]