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The data indicated that chronic stress down-modulated body weight, anti-inflammatory interleukins, occludin, cldn-1, cldn-3, mucin-secreting goblet cells, antioxidant enzymes (glutathione peroxidase, superoxide dismutase, catalase), and autophagia, while up-regulating parameters of damage like colonic FITC–dextran permeability, serum corticosterone/norepinephrine, serum LPS derived from commensal microbiota, proinflammatory cytokines, and apoptosis (Figure 3, mechanism 3)

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Semaglutide focuses primarily on GLP-1 receptor activation, while the cagrilintide peptide also mimics amylin, a hormone that further slows digestion and enhances satiety