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Research is still mapping how these pathways behave

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Common characteristics observed in senescent cells Increased inflammatory signaling (SASP factors such as IL-6, IL-1β, TNF-α in many models) Elevated oxidative stress and reactive oxygen species (ROS) Impaired mitochondrial dynamics (often more fragmented or dysfunctional networks) Reduced regenerative capacity in local tissue microenvironments FOXO4-DRI Mechanism: Disrupting FOXO4–p53 Binding FOXO4 (Forkhead box O4) is a transcription factor that, among other roles, participates in stress response pathways