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The increased expression of Ucp1 induced by Mat1a ASO in BAT was associated with increased peroxisome proliferator-activated receptors (Ppar) alpha (a) , Ppar gamma (g) and adiponectin Q ( Adipoq) expression (Fig
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Preclinical studies showed the ability of ImmTOR to mitigate immunogenicity of pegadricase resulting in sustained control of sUA in uricase-deficient mice 9
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