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In a randomized, placebo-controlled clinical trial, patients undergoing radiotherapy for liver tumors who consumed HRW reported improved quality of life, reduced fatigue, and lower circulating levels of oxidative metabolites, without compromising the antitumor effects of the treatment [10]

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In multiple in vitro and animal models, arginine is metabolized by iNOS to generate nitric oxide (NO), thereby enhancing pro-inflammatory responses, whereas its metabolism by Arg1 produces ornithine and polyamines that support tissue repair ( The coupling between metabolism and epigenetic regulation further reinforces the impact of metabolism on the stability of macrophage polarization