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In controlled human skin studies, microneedling increased the delivery of small cosmetic peptides by 2- to 22-fold over passive diffusion;5 in a separate study, a 31-fold increase in flux of a small peptide was measured after microneedle pretreatment.6 Formulation matters just as much as needles: published hair formulas cluster in the 1–5% copper-peptide range, and the follicle effects appear at far lower concentrations — because copper peptides follow a biphasic curve where too much can inhibit the very cells you want to wake up.1 More is not better

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[DOI] [PubMed] [Google Scholar] 170.Orosco F.L., Lluisma A.O