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The activation of the NF-κB and MAPK pathways in hematopoietic cells and endothelial cells triggers the release of pro-inflammatory cytokines
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Thus, while chromatin ubiquitination is increased in T208A-RNF168-expressing cells, this selectively enhances the recruitment of 53BP1 to sites of DNA damage while suppressing the relocalization of the BRCA1:BARD1 heterodimer
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