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This chronic state of psychological stress can trigger inflammation [119] within the GI tract via the release of corticotropin-releasing hormone (CRH), leading to disruption of both the gut–blood-barrier (GBB) [120,121,122,123,124,125,126] and the blood–brain-barrier (BBB) [127,128,129] through activation of MCs, which can also release CRH on their own [130]
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2 Methods 2.1 Search strategy and databases A structured literature search was conducted across PubMed and Google Scholar to identify studies examining the therapeutic role of apigenin and ellagic acid in polycystic ovarian syndrome (PCOS)
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