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Binding of GABA to GABA A receptor induces the opening of the ligand-gated chloride channel, leading to an increased influx of chloride ions, which results in hyperpolarization

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Hydroxypyridones are able to release iron ions from biologically important structures (e.g., lactoferrin) (Halliwell and Gutteridge, 2015), potentially leading to the production of free radicals