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Type:Guaiazulene
In particular, the derivative with the ester moiety as an R substituent (compound 13 ) was the most active of the compounds, whereas the compounds with carboxylic moiety (compound 14 ) proved to be highly toxic and less selective with an IC 50 higher than 200 µM and a CC 50 of approximately 10 µM on Vero and kB cells
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