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LIHC is characterized by a series of metabolic alterations such as increased glucose uptake and lactate production [91, 92], upregulated de novo lipogenesis and NADPH production [93, 94], accelerated glutamine consumption [95], elevated amino acids metabolism, and GSH synthesis [96–99], as well as attenuated TCA cycles and fatty acid β-oxidation [93, 100, 101] when compared with the non-cancerous sample tissues [102]

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