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Likewise, the effectiveness of switching therapies in persistent DME remains a matter of ongoing debate
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Recent animal studies strikingly illustrate the indispensability of cysteine: combined inhibition of cysteine biosynthesis (deletion of the CSE gene) and GSH synthesis (BSO inhibition of GCS) produced 30% body weight loss in mice within one week — accompanied by loss of white adipose tissue, replacement with brown adipose tissue, transcriptional reprogramming, mitochondrial dysfunction, impaired integrated stress response (ISR) and oxidative stress response (OSR), and loss of glycolytic and TCA cycle intermediates in urine
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