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9 Although the reasons for this are still unclear, one may speculate that Gpx4 is required to allow a “silent” form of cell death that could tentatively switch upon Gpx4 loss/malfunction to a highly inflammatory cell death modality culminating in the release of several proinflammatory lipid mediators

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Non-surgical treatment: Conservative treatment options are usually reserved for partial tears or individuals who would not make good candidates for an operation, such as elderly patients