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Zinc finger protein 488 (ZNF488) activates SCD1 to increase MUFAs synthesis, and zinc finger E-box binding homeobox 1 (ZEB1) under hyperglycemia promotes PUFAs synthesis and ferroptosis sensitivity, while PC-derived micro RNAs (miRNAs) suppress ZEB1, leading to iron accumulation in muscle cells and cancer-associated cachexia (CAC) [171–173]
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