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Tretinoin, a prescription vitamin A derivative, has been called “the most potent and certainly the most widely investigated retinoid for photoaging therapy” by researchers in a 2006 review.49 And a more recent 2022 review notes that studies on tretinoin “consistently” find it to be “efficacious in improving [the] clinical appearance of photoaging.”50 And many nonprescription ingredients, like niacinamide (for melasma),51 vitamin C (for wrinkles),52 and hyaluronic acid (for dry skin), have demonstrated positive outcomes in studies.53 Some of our favorite online dermatology options that we’ve reviewed are Curology, Agency, Prose, and Musely