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Immunity 32, 692 (2010), Abstract Inhibitors of p38 suppress cytokine production in rheumatoid arthritis synovial membranes: does variable inhibition of interleukin-6 production limit effectiveness in vivo?: T.H
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Tetrandrine can enhance the ubiquitination and degradation of spleen tyrosine kinase (Syk) through AhR/non-receptor tyrosine kinase/c-Cbl signaling pathway and regulate the expression of Syk and phospholipase-Cγ, thereby inhibiting osteoclastogenesis and bone destruction in arthritis (90, 91)
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