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10.1056/NEJMoa2024816 [DOI] [PubMed] [Google Scholar] 167.The EMPA-KIDNEY Collaborative Group, Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, et al
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The E167K variant enhances the interaction between TM6SF2 and the PNPLA3 variant I148M, which inhibits the function of PNPLA3 in mediating the transfer of polyunsaturated fatty acids (PUFAs) from TG to phosphatidylcholine, leading to increased accumulation of polyunsaturated TG in the liver and exacerbation of liver injury [271]
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