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To view or add a comment, sign in Pleased to share our new paper in Cell Reports Methods by Cell Press: “SwitchClass distinguishes baseline- and perturbation-aligned features across intermediate molecular states.” In many biological systems, the most interesting signals are not simply “changed” or “unchanged.” They can reflect baseline identity, perturbation response, or transitional molecular programs that sit between states
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This is an important example of why promising laboratory or early clinical findings do not automatically translate into an effective treatment
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