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ERC has a considerable amount of enzymes to regulate glucose metabolism, specifically glucose-6-phosphate dehydrogenase (G6PD) [63], which induces increased ROS levels by activating (1) the NADPH - nicotinamide adenine dinucleotide phosphate located in the plasma membrane of spermatozoa, and (2) NADPH – dependent oxide-reductase, known as diphorase, detected in the middle piece of mitochondrial level [64, 65, 66]
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