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This effect is mediated by the activation of the MAPK signaling pathway, which upregulates the expression of downstream effectors, thereby enhancing HSC proliferation and decreasing IR-induced apoptosis ( Orychophragmus violaceus
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We first evaluated the tolerance of SH-SY5Y cells to Aβ oligomers alone and observed no noticeable cell death or morphological changes at or below 5 µM Aβ treatment for 48 hours (Supplementary Figure 3B)
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