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3.4 The RANK/RANKL/OPG signaling pathway The RANK/RANKL/OPG (receptor activator of nuclear factor-κB/receptor activator of nuclear factor-κB ligand/osteoprotegerin) signaling axis is a central regulator of bone remodeling, coordinating osteoblast–osteoclast coupling and intersecting with immune–inflammatory pathways (51)
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