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Similarly, macrophage polarization exemplifies regulated immunometabolism: pro-inflammatory M1 macrophages exhibit high glycolytic activity to support iNOS-mediated NO production, whereas anti-inflammatory M2 macrophages depend on oxidative phosphorylation for tissue repair functions (58, 59)
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Furthermore, it was also proven that DADS have a renoprotective effect on methotrexate-induced nephropathy, which postures that DADS may have therapeutic value in reducing the chemotherapeutic agents’ effects like methotrexate (Nanjwade et al., 2015)
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