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Also, in neuropathic pain states, methylcobalamin inhibited the ectopic spontaneous discharges from peripheral sensory neurons ( The underlying pathophysiological mechanism is probably neuronal protection by promotion of regeneration of injured nerves ( 3.3.2
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In contrast, the prolyl isomerase cyclophilin D in the mitochondrial matrix is an essential regulator of MPT and the only genetically proven indispensable MPT component (Nakagawa et al., 2005
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