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Previous studies have reported that the decreased levels of cellular antioxidants and elevated free radicals in the inflammatory articular cavity may lead to intensified RA.[14] The ROS accumulate in the synovial fluid and peripheral blood of RA patients and can cause degenerative changes to joins, if their production and release are not balanced by sufficient antioxidants.[15] The results of our study reveal that GSH in RA SFs MH7A significantly decreased the secretion of ROS, whereas the release of ROS was recovered in the presence of GSH inhibitor

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To understand the effectiveness and safety of the use of DSIP in treating sleep problems in humans, more clinical studies are necessary