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Individuals with active cancer or a history of malignancy should avoid the peptide unless under medical supervision, as effects on tumor growth have not been adequately studied
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IGF-1 gene expression in VSMCs is dependent on numerous factors, including thrombin, tumour necrosis factor-alpha (TNFα), angiotensin II, oxidized low-density lipoprotein (ox-LDL), and reactive oxidative species (ROS) (61–66)
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