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Protein kinase C β type isoform 2 (PKCβII) is able to recognize the initial lipid peroxidation, promote the phosphorylation of ACSL4 on Thr328 to activate phospho-ACSL4, and facilitate the incorporation of PUFA into PLs, leading to the termination of the cells ( According to recent findings, membrane lipids are key regulators of ferroptosis
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