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In addition, essential fats, proteins, non-digestible carbohydrates, probiotics and polyphenols all induce shifts in the microbiome with consequences for host metabolic and immunologic markers (Reference Singh, Chang and Yan80) Therefore, attempts to investigate effects of a specific diet in a population already adhering to that diet may be of low yield and/or limited by small changes in their microbial diversity

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Potential effects include injection‑site irritation, fluid retention, joint aches, tingling, changes in blood sugar or lipids, and shifts in IGF‑1

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