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While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers
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found that daunorubicin and cytarabine treatment resulted in the increased expression and activity of enzymes involved in the ceramide pathway, leading to a decrease in ceramide levels and an increase in ceramide 1- and sphingosine 1-phosphate levels
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