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In individuals with Alzheimer's disease (AD), pyramidal neurons show a significant decrease in mitochondrial DNA copy number (mtDNA-CN) compared to those without cognitive impairment (147)
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The reason that could explain the poor infection outcome of GSH deficient mice is that the GSH:GSSG ratio directly affected the production of IL-12 from macrophages and this caused a reduction of IFN-γ production from NK or T cells, which could in turn activate the microbicidal activity of macrophages to kill the intracellular bacteria [104]
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