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Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice | Inflammation Research | Springer Nature Link

Tranexamic acid, on the other hand, treats melasma specifically and has fewer effects on the body as a whole

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Commentary Medicine has adopted a rather biased method of study as its gold standard — “double blind controlled studies.” This favors research on patentable/profitable synthetic chemicals, or procedures, where study costs can be recovered, over outcome-based reporting