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(Native, unmodified recombinant human IGF-1, sold as mecasermin/Increlex, is FDA-approved only for a narrow pediatric growth-failure indication and is chemically distinct from the LR3 analog.) In the US it is manufactured and sold almost exclusively as an unregulated "research chemical" labeled "not for human consumption," a labeling practice peptide vendors use to avoid marketing it as an unapproved drug

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618 Pycnogenol may benefit cardiovascular health through a variety of mechanisms, such as inhibiting inflammation and clotting, reducing oxidative stress, and improving endothelial function