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The oncolytic effect is attributed to the upregulation of the extrinsic and intrinsic apoptosis-associated proteins, including caspase-3, caspase-8, and caspase-9, and suppression of metastasis-associated protein VEGF, MMP-9, urokinase-type plasminogen activator (uPA), and Cyclin- D1, as validated by immunohistochemistry (IHC) staining
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