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Interestingly, bystander uninfected CD4 + T cells were also found to have slightly increased HIF-1α expression ( + T cells from PLWH on ART were additionally found to have significantly higher levels of HIF-1α expression than HIV-uninfected individuals, which correlated with surface GLUT1 abundance ( In contrast to the effects of HIF-1α described, HIF-2α has been found to repress transcription at the HIV-1 promotor (Zhuang et al., 2020)